Significance of Compatibility studies
Compatibility studies involve a series of analyses focused on the interactions between a drug and its excipients to ensure that they do not chemically interact in ways that compromise the formulation’s stability and efficacy. These investigations include various tests, such as FTIR, to evaluate whether active ingredients and excipients can coexist without adverse reactions or destabilizing effects. Ultimately, compatibility studies aim to confirm that formulation components work harmoniously together to maintain effectiveness over time.
Synonyms: Consistency evaluation, Compatibility assessment
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The concept of Compatibility studies in scientific sources
Compatibility studies involve investigations and tests to evaluate the interaction between active ingredients and excipients in pharmaceutical formulations, ensuring they do not negatively interact and thus preventing incompatibility issues.
From: World Journal of Pharmaceutical Research
(1) Evaluations of the physical and chemical interactions between a drug and excipients to ensure their suitability in a formulation.[1] (2) Tests and analyses conducted to determine the suitability of combining specific drugs with excipients, assessing their interactions and stability.[2] (3) Investigations conducted to ensure that the active ingredient and excipients can interact without significant chemical changes or stability issues.[3] (4) Investigations conducted to assess whether a drug and excipients interact chemically or physically in a formulation.[4] (5) Evaluations performed to determine whether the drug and excipients interact chemically or physically, affecting their efficacy.[5]
From: AYU (Journal of Research in Ayurveda)
(1) Tests conducted to ensure that the active ingredients and excipients do not adversely interact with each other.[6]