Significance of Combination therapy
Combination therapy, as described in the text, is the use of multiple treatments together to enhance therapeutic effects. It is utilized across various fields, including Ayurveda, Science, Psychiatry, and Health Sciences. This approach involves using different drugs, modalities, or therapeutic approaches simultaneously. The goal is to achieve better outcomes, such as improved efficacy, reduced side effects, and the prevention of drug resistance. Specific examples include combining antibiotics, plant extracts, and medications for conditions like cancer, diabetes, and hypertension.
Synonyms: Combination treatment, Multimodal therapy, Polytherapy, Co-treatment, Adjunct therapy, Adjunctive therapy, Concomitant therapy
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Combination therapy'
In Hinduism, combination therapy involves using different treatments together. This could include therapies to maximize response, minimize side effects, or target multiple aspects of a condition. Examples include combining drugs, plant extracts, or traditional remedies like Kulattha Yusha and Vidanga Churna.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) This therapy, involving Ayurvedic treatments, leads to an improvement in the quality of life for patients with end-stage OA.[1] (2) This is a treatment approach where different therapies are used together, where appropriate, to maximize response and minimize side effects, forming part of the strategy.[2] (3) This involves using a combination of treatments, such as antibiotics and plant extracts, to achieve a greater effect or address multiple aspects of a condition, as discussed in the text.[3] (4) This was found to be very useful in establishing the normal functioning of the thyroid gland.[4] (5) This type of treatment, involving Kulattha Yusha and Vidanga Churna, shows potential efficacy in managing hypothyroidism based on study results.[5]
From: Journal of Ayurvedic and Herbal Medicine
(1) Another approach of drug delivery is to form PEG-DOX- Cur prodrug nanoparticle for simultaneous delivery of doxorubicin (DOX) and curcumin (Cur) as a combination therapy to treat cancer.[6]
The concept of Combination therapy in scientific sources
Combination therapy involves using multiple treatments simultaneously to improve efficacy and manage side effects. It encompasses various approaches like combining medications, therapies, or modalities. It is used across diverse conditions, including osteoporosis, infections, hypertension, cancer, and viral infections, aiming to enhance effectiveness and prevent resistance.
From: South African Journal of HIV Medicine
(1) Combination therapy, which is the optimal management strategy for CCM, involves three key elements: antifungal treatment, intracranial pressure management through CSF drainage, and appropriately timed immune reconstitution with ART.[7] (2) Using multiple medications is a treatment approach for meningitis in individuals with AIDS in Uganda.[8] (3) Since then a further seven randomised controlled trials and numerous open label demonstration studies have led to the registration of combination therapy, with tenofovir and emtricitabine or related variations thereof as effective tools in the prevention of human immunodeficiency virus transmission to uninfected persons.[9]
From: South African Family Practice
(1) Metformin can be effectively used in combination therapy with other oral hypoglycaemic agents or insulin, allowing for additive beneficial effects in managing diabetes.[10] (2) A therapeutic approach where DPP-4 inhibitors are effective, used with other oral antidiabetic agents.[11] (3) It involves the use of both behavioral and pharmacological interventions to treat sleeplessness, often starting with both and then tapering off medication while continuing behavioral techniques.[12]
From: South African Journal of Physiotherapy
(1) Combination therapy is one of the treatment options that have metamorphosed in the last decades from a more conventional and conservative approach to the use of technology.[13] (2) Combination therapy, involving four-cell baths and rising-temperature arm baths, was implemented in a first observational study, and the success attained therefore justifies using this concept of therapy as a reference therapy in the present comparison study.[14] (3) This is a treatment approach that includes nucleoside reverse transcriptase inhibitors as well as protease inhibitors, which helps to minimize resistance to drugs developing.[15]
From: International Journal of Pharmacology
(1) The results revealed that the incidence of hospitalization in this treated group was only 0.77% with 0% death in comparison to the placebo by 28 days.[16] (2) This involves using phytochemical extracts and commercial antibiotics together, potentially increasing clinical efficacy and widening the spectrum of antibacterial activity.[17] (3) This in rheumatoid arthritis is acknowledged to give a better remission of disease than monotherapy.[18]
From: Asian Journal of Pharmaceutics
(1) In addition, this formulation makes combination therapy – drug-herb, drug-drug, and herb-herb – possible and these combinations reduce side effects and increase patient compliance.[19] (2) This is an effective way in the treatment of diseases by using drugs of same or different therapeutic effects.[20] (3) The use of multiple drugs to treat a condition, such as atherosclerosis and Type II diabetes mellitus.[21]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Combination therapy was evaluated for its analgesic effect on chronic plantar pain, particularly through the approach of targeting myofascial trigger points.[22] (2) A successful treatment approach for one infected person involved administering LPV/r alongside other pharmaceutical agents, leading to positive responses even when prior treatments like interferon were ineffective.[23] (3) Combination therapy involving d-penicillamine and n-acetylcysteine (NAC) was evaluated for its efficacy in treating lead poisoning among opium addicts, focusing on mitigating the associated oxidative stress experienced by these patients.[24]
From: Sustainability Journal (MDPI)
(1) Antimicrobial combination therapy, involving biomolecules, offers advantages such as treating mixed infections, augmenting antibacterial activities, reducing development time for new agents, and preventing resistant microbes.[25]
From: International Journal of Pharmacology
(1) The administration of two or more treatments simultaneously, found to be most effective in maintaining antioxidant levels in this study.[26] (2) Combination therapy involves using multiple active agents together, and in the context of acute lung injury, combining agents like melatonin and zafirlucast can potentiate their beneficial effects.[27] (3) Combination therapy is a treatment approach where artesunate is used alongside other medications, a practice that has been studied in relation to its toxicity.[28]
From: South African Journal of Psychiatry
(1) The use of multiple medications, such as lithium and antipsychotics, which can impact the duration of hospital stays for individuals.[29] (2) This refers to the use of multiple medications together, such as antidepressants with mood stabilizers or antipsychotics, to manage the symptoms of bipolar depression.[30] (3) This refers to the use of multiple therapeutic approaches simultaneously, which is frequently employed to address the complexities of Attention Deficit Hyperactivity Disorder, often involving both medication and psychological interventions.[31]