Significance of Clinical trial
Clinical trial is a research study involving human participants to evaluate the safety and effectiveness of medical interventions. Across various disciplines like Ayurveda, Science, Psychiatry, and Health Sciences, the term consistently describes studies testing new treatments, drugs, or therapies. These trials often involve controlled experiments, randomized groups, and ethical considerations, contributing to evidence-based practices and guidelines. The need for more well-designed trials is often highlighted.
Synonyms: Research study, Experimental study, Clinical study, Drug trial, Study, Experimentation, Investigation, Test, Assessment
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Clinical trial'
In Hinduism, a clinical trial involves research on human participants to assess the safety and effectiveness of medical interventions like Ayurvedic treatments, often comparing them to modern medicine for various conditions.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) A clinical trial was conducted, where patients suffering from Dushta Vrana were selected randomly and subjected to the trial to evaluate the efficacy of Jatyadi Taila and Ghrita.[1] (2) Clinical trial is required to prove the functional relationship in between Jatharagni and Dhatvagni, which is important for understanding their interrelationship.[2] (3) The therapeutic efficacy of T. cordifolia extensively used in Indian system of Medicine has been established through modern testing and evaluation through clinical trials.[3] (4) Clinical Trial was conducted to comparatively study the efficacy of Marma Chikitsa and stimulation of Marma by TENS in the management of Lumbar Spondylosis.[4] (5) This is a study conducted to access the efficacy of Prasarinyadi Taila in the management of Diabetic Peripheral Neuropathy related to Madhumeha Janya Suptavata.[5]
From: Journal of Ayurvedic and Herbal Medicine
(1) As the global mass is showing interest for Ayurvedic drugs for its cost effectiveness and higher safety index, it’s the need of the hour to validate A. longifolia as a most suitable drug to treat Covid 19 cases pending further in-depth studies.[6] (2) Further research, including well-designed these, is needed to validate these findings, determine optimal dosages, and establish standardized Neem leaf-based interventions for chronic wound management.[7] (3) Preclinical and of these are needed to evaluate biocompatibility & safety before neem can conclusively be recommended as an intracanal irrigating solution.[8] (4) This phrase refers to the investigation, which was conducted on 34 patients, and some patients passed stone within one month of treatment.[9] (5) These are the studies carried out to assess the efficacy of different Ayurvedic formulations in treating Amavata.[10]
From: International Research Journal of Ayurveda and Yoga
(1) This review study suggests that to support the immunomodulatory effect of Suvarnprashan, multicentric controlled this using biomarkers should be conducted.[11] (2) Total numbers of 80 patients were registered for the open labelled interventional one from the OPD and IPD of Kayachikitsa Department Govt. Ayurvedic College and Hospital, Ghy-14.[12] (3) The following choorna compounds were utilized for the present of this kind of study: Hareetakyadi, Ashwagandhadi, and Shatavaryadi Choorna.[13] (4) The assessment of this study is done by the severity of symptomatology.[14] (5) The study drug, Bhudhatryadi Yoga, was selected for this trial to evaluate its effects.[15]
The concept of Clinical trial in scientific sources
Clinical trials are research studies evaluating the safety and efficacy of medical interventions in humans. These trials test new treatments, drugs, or therapies under controlled conditions, often involving specific populations or conditions.
From: Journal of Public Health in Africa
(1) Clinical trials are research studies conducted on human volunteers to evaluate the safety and efficacy of new treatments; defining robust clinical trials is essential for plant-based medications.[16] (2) Clinical trials are research studies that evaluate the safety and effectiveness of new medical treatments or interventions, and they are essential for advancing medical knowledge and improving patient care.[17] (3) Clinical trial refers to studies designed to examine the effect of interventions like Moringa oleifera supplementation.[18]
From: South African Journal of HIV Medicine
(1) Research studies involving human participants to evaluate the effectiveness and safety of medical interventions, with analysis provided in the HIV Treatment Bulletin.[19] (2) Clinical trials and clinical consultancy services form an integral component of the HIV programme.[20] (3) It is the studies that showed the risk of InSTI resistance was modest in those settings.[21]
From: African Journal of Primary Health Care and Family Medicine
(1) Apart from disease-specific databases, there is also a need for treatment-specific registries, and these are particularly relevant in areas where clinical trials are difficult to perform owing to small patient numbers and lack of industry interest, as well as for therapies in need of global development or improvement.[22] (2) Clinical trials involve self-reported adherence to antiretroviral medication among participants, which demonstrates the use of patient-reported data in research settings to evaluate medication compliance.[23] (3) A research study comparing co-trimoxazole versus amoxicillin for treatment of pneumonia in Pakistan.[24]
From: International Journal of Pharmacology
(1) The only compound from a PTP1b discovery effort to make it to these thus far (ertiprotafil) has been shown to derive its efficacy from additional mechanisms, including agonism of PPAR family members-37.. These showed that this allosteric site exists within 20 angstroms of the peptide-binding groove in a pocket formed by helices 3 and 6 of PTP1b.[25] (2) Clinical trials, antibiotics, probiotics, pouchitis and IPAA were searched in all relevant databases especially Pubmed Web of Science, Scopus, Cochrane and Google Scholar for studies reported use of probiotics or antibiotics in treatment of IPAA from 1965 up to December 2009; thirteen clinical trials were included in the meta-analysis.[26] (3) Clinical trial is a research study to evaluate a medical, surgical, or behavioral intervention, and this randomized clinical trial was performed in Dr. Shariati Hospital of Tehran University of Medical Sciences.[27]
From: South African Family Practice
(1) Clinical trials provide evidence for ACE inhibitor combinations in hypertensive patients with type 2 diabetes, influencing treatment guidelines and clinical practice.[28] (2) Numerous randomised controlled clinical trials (RCTs) showing a positive effect of HRT on BMD of both the spine and the hip exist, according to the text.[29] (3) Clinical trials and epidemiological studies have limitations in formulating the severity of asthma based on prescribed steps of treatment, according to the Global Initiative for Asthma (GINA) Main Report 2020.[30]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Clinical trials have standard protocol items defined by the SPIRIT 2013 Statement.[31] (2) Clinical trials in Alzheimer’s disease utilize inventories to assess activities of daily living, contributing to the evaluation of treatments and interventions.[32] (3) Clinical trials conducted overseas by US interests must adhere to ethical requirements, and data from trials with reported lapses in ethical protections should not be accepted by regulatory bodies.[33]
From: Sustainability Journal (MDPI)
(1) A clinical trial was conducted to assess the efficacy of deep cervical flexor muscle training on neck pain and related issues in school teachers.[34] (2) In clinical trials, RFID technology is used for drug tracking and combating counterfeit products, as noted by 1.7% of participants.[35] (3) A future line of research intended to run with a significant number of users during a longer period of time, to objectively evaluate the quality of life and physical condition.[36]
From: South African Journal of Psychiatry
(1) The text refers to guidelines for good practice in the conduct of clinical trials with human participants in South Africa, ensuring ethical and rigorous research.[37] (2) Markowitz et al. presented preliminary data for two treatment modalities in a randomised clinical trial that paralleled that of the NIMH Collaborative Research Program.[38] (3) This is the main topic of the workshop, which addresses the steps to success, compliance and standard operating procedures, clinical outcome measures and endpoints, design of investigator initiated protocols, issues regarding patient recruitment and selection, and ethical aspects conducting clinical trial research.[39]
From: International Journal of Pharmacology
(1) The findings suggest that the methanol sub-fraction is safe enough to be considered for further evaluation in human clinical trials.[40] (2) Clinical trials are research studies conducted on human volunteers to evaluate the safety and efficacy of new medical treatments or interventions.[41] (3) Clinical trials are research studies involving human participants to evaluate the safety and effectiveness of new medical treatments.[42]
From: Journal of Public Health in Africa
(1) Clinical trials for mpox therapeutics and vaccines are prioritized to improve efficacy and promote regional self-reliance in vaccine production and availability.[43]
From: Religions Journal (MDPI)
(1) Clinical trials are research studies that evaluate the safety and effectiveness of new medical treatments, interventions, or diagnostic procedures in human participants.[44] (2) The study was registered with Clinical Trials identification number: NCT 01866670, indicating that it is a registered clinical trial following specific protocols and guidelines.[45] (3) Has shown improvement in clinical trials for mood and cognitive disorders such as major depression and Alzheimer’s disease.[46]