Significance of Chronic constriction injury
Chronic constriction injury is a method employed in experimental settings to induce neuropathic pain primarily in animals. This involves tightening ligatures around the sciatic nerve, effectively simulating nerve injury, which helps researchers investigate pain mechanisms. It functions similarly to other methods, such as sciatic nerve ligation, and provides a specific model to study the effects of nerve injury and potential treatments for neuropathic pain. This approach is crucial for advancing understanding in pain research.
Synonyms: Nerve compression, Neuropathic pain, Peripheral nerve injury, Nerve trauma
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The concept of Chronic constriction injury in scientific sources
Chronic constriction injury (CCI) is a surgical method that induces neuropathic pain in experimental models by tightening ligatures around the sciatic nerve, serving as a crucial tool for studying pain mechanisms similar to sciatic nerve ligation.
From: World Journal of Pharmaceutical Research
(1) A specific experimental model of neuropathic pain where the sciatic nerve is subject to loose ligation to simulate nerve injury.[1] (2) A surgical procedure used to induce neuropathic pain in experimental animals by tightening ligatures around the sciatic nerve, mimicking nerve injury to study pain mechanisms.[2]
From: Ancient Science of Life
(1) A form of nerve injury used in models to study neuropathic pain, similar to sciatic nerve ligation.[3]