Significance of CGMP
CGMP, or cyclic guanosine monophosphate, is a key signaling molecule with diverse functions. Science highlights its role in antioxidant activity and cellular function regulation, where its increase can protect against lipid peroxidation. Health Sciences emphasizes its role in vasodilation and antidepressant-like effects. It is also a second messenger involved in cellular signaling pathways and blood pressure regulation. Furthermore, the term "cGMP" also refers to Current Good Manufacturing Practices, which are the FDA regulations for pharmaceutical production.
Synonyms: Current good manufacturing practice, Quality assurance standards, Gmp, Good manufacturing practice, Manufacturing standards
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of CGMP in scientific sources
CGMP is referenced in two distinct ways: Current Good Manufacturing Practices (regulations for quality in manufacturing) and cyclic guanosine monophosphate, a signaling molecule. The latter plays roles in smooth muscle relaxation, vasodilation, and various cellular pathways.
From: International Journal of Pharmacology
(1) Sildenafil citrate is a potent and selective inhibitor of cyclic guanosine monophosphate specific phosphodiesterase type 5.[1] (2) This is generated from GTP through the activation of soluble guanylyl cyclase by nitric oxide.[2] (3) Cyclic guanosine monophosphate, a signaling molecule that vitamin C may stimulate, affecting calcium metabolism.[3] (4) cGMP is a molecule whose reduction has been associated with antidepressant-like effects in animal models, specifically in the forced swimming test.[4] (5) cGMP is produced in nitroprusside-stimulated rat colonic ion transport, alongside PGE2.[5]
From: Asian Journal of Pharmaceutics
(1) This practice can solve issues related to excipients, but it still affects the excipient manufacturing process, increasing time and cost.[6]
From: International Journal of Pharmacology
(1) This is a cyclic nucleotide that seems to play a role as an antioxidant, and its increase, facilitated by sildenafil and dipyridamole, is associated with protection against lead-induced lipid peroxidation.[7] (2) cGMP is a cyclic nucleotide that plays a prominent role in the regulation of cellular functions, and its breakdown is inhibited by PDE5 inhibitors like sildenafil.[8] (3) cGMP is a molecule formed in target cells, activated by nitric oxide, and is involved in cGMP signaling pathways.[9]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) cGMP, or cyclic guanosine-3',5'-monophosphate, represents the main effector for Nitric oxide activity, as it is formed from GTP by soluble guanylate cyclase after NO-mediated binding occurs.[10]