Significance of Brain homogenate
Brain homogenate, a key element in various scientific fields, involves processing brain tissue into a uniform mixture for detailed biochemical analysis. This technique is crucial in experimental research, allowing scientists to study biochemical markers, enzyme activities, and the effects of chemicals like dopamine. It is also used to quantify biochemical parameters, such as BDNF and TNF-α, relevant to conditions like dementia, and to measure neurotransmitter levels. Brain homogenate plays a vital role in understanding brain function and the impact of different substances on brain tissue.
Synonyms: Brain tissue, Cerebral homogenate
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The concept of Brain homogenate in scientific sources
Brain homogenate is processed brain tissue used for biochemical analysis. Researchers use it to measure neurotransmitter levels, enzyme activity, and biochemical markers related to diseases like dementia, often in experimental research.
From: International Journal of Pharmacology
(1) This was transferred to bottle containing 8 mL of ice cold absolute alcohol and kept for 1 h at 0°C for GABA estimation.[1] (2) A study discusses the inhibition of respiration in rat brain homogenates through anticonvulsant and antiproteolytic properties of certain compounds.[2] (3) Researchers observed AChE levels in these, rather than estimation in specific brain components.[3]
From: Asian Journal of Pharmaceutics
(1) The substance prepared immediately before use by removing the brains and homogenizing with 0.9% saline.[4] (2) The present work aimed to study the neuroprotective mechanisms of ischemic preconditioning on Rho-kinase and nitric oxide levels in this material of rats as well as the effect of NOS inhibition.[5]
From: The Malaysian Journal of Medical Sciences
(1) A mixture obtained from brain tissue used for studying the effects of chemicals like dopamine.[6]
From: South African Journal of Psychiatry
(1) Brain homogenate was used in the experiments involving rotenone, which is used to measure lipid peroxidation and superoxide radical formation in rat brains.[7]
From: International Journal of Pharmacology
(1) Tissue samples from the brain that have been broken down into a uniform mixture, used for biochemical analysis.[8]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) About the brain homogenate, Fer-Me did not evidence any hydrolysis profile, showing high stability during the six hours of incubation at 37 ◦ C.[9]