Significance of Blood brain barrier
The blood-brain barrier (BBB) is a selective permeability barrier that separates circulating blood from the brain's extracellular fluid and protects it from harmful substances while allowing essential nutrients to pass through. This barrier presents significant challenges for drug delivery to the central nervous system, as it restricts access to most therapeutic agents. Understanding the functionality of the BBB is crucial for developing effective treatments for various neurological disorders, as it limits the effectiveness of many medications designed to target the brain.
Synonyms: Blood-cerebrospinal fluid barrier
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The concept of Blood brain barrier in scientific sources
The Blood Brain Barrier (BBB) is a crucial selective permeability barrier that safeguards the brain by blocking harmful substances while allowing essential nutrients to pass, highlighting its importance in treatments like Brahmi Ghrita for psychological disorders.
From: The Malaysian Journal of Medical Sciences
(1) Blood-brain barrier, disruption of which was associated with accumulation of toxic blood borne substances in the brain parenchyma, neuroinflammation, and cognitive decline in the animal study.[1] (2) This is a protective barrier that separates the blood from the brain, and its permeability can be affected by conditions such as stroke, impacting brain health.[2] (3) Blood-brain barrier is compromised by reactive astrocyte, and it allows the recruitment of microglia and circulating macrophages to enter the brain parenchyma.[3] (4) The blood-brain barrier is a protective mechanism that controls what substances enter the brain, and disruption of this barrier can lead to early cerebral injury.[4] (5) The protective barrier that limits the passage of substances from the bloodstream into the brain, differing between species.[5]