Significance of Bioavailability
Bioavailability is a crucial concept in pharmacology, referring to the extent and rate at which an active ingredient or drug becomes available at the site of action after administration. It determines how effectively a drug exerts its therapeutic effects and is influenced by factors such as the solubility of the compound. Essentially, bioavailability represents the proportion of a drug that enters systemic circulation and is available for therapeutic action, making it a key consideration in drug development and formulation.
Synonyms: Absorption, Availability, Bioactivity, Assimilation, Distribution, Accessibility
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Bioavailability in scientific sources
Bioavailability is the measure of how effectively an active ingredient is absorbed and becomes available at the site of action within the body, influenced by factors such as timing and the presence of enhancing compounds.
From: The Malaysian Journal of Medical Sciences
(1) This refers to the rate and extent to which a drug enters the systemic circulation, and the text mentions that CYP2B6 polymorphisms affect both gene expression and bioavailability of the enzyme.[1] (2) This is a property of vitexin that is discussed in the text, including its sources, safety profile, and possible molecular mechanisms of action in Parkinson’s disease.[2] (3) This refers to the extent to which a substance is absorbed and available to the body, and polyphenols have low bioavailability in vivo.[3] (4) The degree and rate at which propranolol is absorbed into the systemic circulation, which was greater in cirrhotic Malay patients compared to Caucasians.[4]