Significance of Bcl-2 protein

Bcl-2 protein is a crucial apoptosis-regulating protein that plays a significant role in controlling cell death and is often targeted in cancer therapy. It functions as an anti-apoptotic protein, preventing cell death; however, its downregulation suggests increased apoptosis. In specific cases, such as in patients with the mtDNA 10398G variant, Bcl-2 expression is decreased compared to Bax, highlighting a potential imbalance in apoptosis regulation. This emphasizes the importance of Bcl-2 in both cancer progression and therapeutic approaches.

Synonyms: Anti-apoptotic protein, B-cell lymphoma 2

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The concept of Bcl-2 protein in scientific sources

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