Significance of Bcl-2 protein
Bcl-2 protein is a crucial apoptosis-regulating protein that plays a significant role in controlling cell death and is often targeted in cancer therapy. It functions as an anti-apoptotic protein, preventing cell death; however, its downregulation suggests increased apoptosis. In specific cases, such as in patients with the mtDNA 10398G variant, Bcl-2 expression is decreased compared to Bax, highlighting a potential imbalance in apoptosis regulation. This emphasizes the importance of Bcl-2 in both cancer progression and therapeutic approaches.
Synonyms: Anti-apoptotic protein, B-cell lymphoma 2
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The concept of Bcl-2 protein in scientific sources
Bcl-2 protein is an apoptosis-regulating protein essential for controlling cell death, and it is frequently targeted in cancer therapy due to its significant role in preventing apoptosis in cancerous cells.
From: World Journal of Pharmaceutical Research
(1) An anti-apoptotic protein that helps prevent cell death; its downregulation indicates increased apoptosis.[1] (2) An apoptosis-regulating protein that plays a critical role in controlling cell death, often targeted in cancer therapy.[2]
From: The Malaysian Journal of Medical Sciences
(1) An anti-apoptotic protein that is decreased in expression compared to Bax in patients carrying the mtDNA 10398G variant, indicating a potential imbalance in apoptosis regulation.[3]