Significance of Autoimmunity
Autoimmunity, according to Ayurveda, science, and health sciences, is when the immune system mistakenly attacks the body's own cells and tissues. This can lead to various diseases, including multiple sclerosis, diabetes, and rheumatoid arthritis. The process involves the immune system failing to distinguish between self and non-self antigens, resulting in autoantibody production. Factors like vitamin D and gut microbiota can influence this process. Ultimately, autoimmunity is a complex biological paradox where the body attacks itself, leading to a range of health issues.
Synonyms: Self-immunity, Autoimmune response, Autoimmune disease, Immune dysregulation, Immune system dysfunction, Immune response disorder
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Autoimmunity'
In Hinduism, autoimmunity describes the body's immune system attacking its own tissues, a biological paradox. This modern pathology aligns with disharmony between Dosha and Dhatu, indicating an obstruction in the disease process, leading to conditions like Lichen Planus and potentially multiple sclerosis.
From: International Research Journal of Ayurveda and Yoga
(1) Presence of HLA DR antigen indicates an autoimmune basis of a disease like oral submucous fibrosis.[1] (2) A suspected factor in the pathogenesis of Oral Submucous Fibrosis.[2]
From: Journal of Ayurveda and Integrated Medical Sciences
(1) Autoimmunity is a biological paradox in which the cells and tissues of the body itself react against antigens of the individual’s own tissue, and Lichen Planus is also appearing to be such a disease.[3] (2) This is a process where the immune system attacks the body's own cells, and it is considered a main cause of multiple sclerosis.[4] (3) Autoimmunity is the condition where there is an abnormal activation of T or B – cells, or both, without evidence of other causes, resulting in the body attacking its own tissues.[5] (4) This concept in modern pathology aligns with the complex presentation of disharmony between Dosha and Dhatu with obstruction in the disease process.[6] (5) This is a state of the body where the immune system fails to distinguish between self and non-self antigens and reacts by producing autoantibodies against the body's own tissue antigens.[7]
The concept of Autoimmunity in scientific sources
Autoimmunity is a condition where the immune system mistakenly attacks the body's own tissues and cells. This can lead to various diseases like rheumatoid arthritis, Hashimoto's Thyroiditis, and type 1 diabetes. Factors like vitamin D, gut microbiota, and regulatory T-cells are involved in modulating this process.
From: The Malaysian Journal of Medical Sciences
(1) An immune response directed against the body's own tissues, considered a central mechanism in the development of the disease.[8]
From: International Journal of Pharmacology
(1) The development of this may be lead to by mediating autophagy through auto-immunoglobulin secretion.[9] (2) Hyperhomocysteinemia, inflammation, and this are related.[10] (3) Iodine acts as an inducing factor in autoimmunity of thyroid gland according to the text.[11]
From: Asian Journal of Pharmaceutics
(1) A condition where the body's immune system attacks its own tissues, potentially contributing to HSP.[12]
From: Journal of Public Health in Africa
(1) Modulation of NF- κ B signaling as a therapeutic target in this disease is mentioned in the Journal of Biomolecular Screening.[13]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Autoimmunity can be influenced by the interplay of stress hormones, proinflammatory cytokines, and antiinflammatory cytokines.[14] (2) Autoimmunity is a potential mechanism through which Toxoplasma gondii infection might influence type-1 diabetes, possibly by inducing autoantibodies or other immunologic processes that decrease insulin secretion.[15] (3) It is a condition in which the immune system mistakenly attacks the body's own tissues and organs, leading to chronic inflammation and tissue damage.[16]
From: International Journal of Pharmacology
(1) Vitamin D plays a role in suppressing dendritic cells, which are involved in the production of autoimmunity.[17] (2) This is a condition that is linked to IL-6 and can involve the immune system attacking the body's own tissues.[18] (3) Autoimmunity is a health condition in patients that may experience beneficial effects from the replacement of amalgam.[19]