Significance of Amphotericin B
Amphotericin B is an antifungal medication used to treat severe fungal infections. It is often administered intravenously and is a first-line treatment for mucormycosis. Amphotericin B is also used in treating cryptococcal meningitis and various forms of leishmaniasis. While highly effective, it is known for its toxicity. It is also used in antifungal susceptibility testing and is a standard drug for comparison.
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The concept of Amphotericin B in scientific sources
Amphotericin B is a versatile antifungal medication used to treat serious fungal infections, including cryptococcal meningitis and mucormycosis. It's administered intravenously and is often a first-line treatment or standard for comparison in studies. It also shows leishmanicidal activity and is used in various research settings.
From: South African Journal of HIV Medicine
(1) Amphotericin B is an antifungal medication used to treat severe fungal infections, and recommended first-line therapy includes early surgery plus liposomal amphotericin B or an echinocandin.[1] (2) This is the brand name of an antifungal antibiotic, used to treat systemic fungal infections and oral candidiasis, according to the provided information about the medication.[2] (3) In patients with suspected CM IRIS who have severe symptoms or deteriorate with the initial approach, the panel recommends treating with amphotericin B plus fluconazole until the CSF culture is confirmed as negative.[3] (4) A specific medication was tested against the fungus to determine its effectiveness in treating the infection, as part of the antifungal susceptibility testing.[4] (5) Amphotericin B is a treatment recommended in the first Southern African CM guideline in 2008, administered at 1 mg/kg/day for 2 weeks, known to quickly reduce the cryptococcal burden in cerebrospinal fluid.[5]
From: International Journal of Pharmacology
(1) This is one of the current medications used to treat leishmaniasis, but it has disadvantages, including side effects and resistance.[6] (2) This is one of the antifungals developed from the first polyene antifungals, which were obtained from Streptomuces griseus fermentation.[7] (3) An antimicrobial agent ordered from FlowLab, likely used to prevent fungal contamination in cell cultures.[8] (4) Amphotericin B was used as a standard control to assess antifungal activity in the antimicrobial assays.[9] (5) A potent antifungal agent that also exhibits leishmanicidal activity, used as a positive control in the study.[10]
From: Asian Journal of Pharmaceutics
(1) The potential ant fungal agent Amphotericin-B was incorporated into nanosphere at various concentrations and compared with that of free drug in terms of percentage.[11] (2) A potential antifungal agent, orally and parentally, having a good safety profile with reduced cost of treatment when using nanocochleates.[12] (3) A polyene antifungal antibiotic considered the single most reliable drug for treating life-threatening systemic fungal infections.[13]
From: The Malaysian Journal of Medical Sciences
(1) This is a medication used in treating the cryptococcosis, and it was administered alongside another medication to treat the patient.[14] (2) An antifungal agent used in the study that displayed the most effectiveness against various moulds.[15]
From: South African Family Practice
(1) Pretreatment regimens for adverse events related to the infusion of this drug were studied, addressing potential complications.[16] (2) This is a medication that is administered to patients, and it is used in combination with fluconazole to treat the condition, and the study looks at the dosages and adherence to treatment.[17]
From: Onderstepoort Journal of Veterinary Research
(1) This is an antifungal agent added to blood culture techniques to reduce contamination, however it was found to suppress the growth of the control culture and therefore its use was discontinued.[18]
From: African Journal of Primary Health Care and Family Medicine
(1) This is a medication that is used for the treatment of cryptococcal meningitis, and it is the preferred and most effective drug for serious systemic fungal infections.[19]
From: International Journal of Pharmacology
(1) A drug formulation used in leishmaniasis treatment, noted to be more toxic compared to pentavalent antimonials.[20] (2) Amphotericin B is a substance used to induce kidney damage in Wistar rats, allowing for the evaluation of nephroprotective agents like Solanum nigrum extract.[21] (3) An antifungal medication that has shown alterable susceptibility in Aspergillus fumigatus.[22]