Significance of Amphotericin B
Amphotericin B is an antifungal medication primarily used intravenously to treat serious fungal infections such as invasive pulmonary aspergillosis and mucormycosis. It is recognized as the first-line treatment for mucormycosis due to its effectiveness in combating severe fungal infections and is the drug of choice for primary amoebic meningoencephalitis (PAM). Amphotericin B works by binding to ergosterol in fungal cell membranes, leading to cell death, and is often used as a reference standard in antifungal activity studies.
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The concept of Amphotericin B in scientific sources
Amphotericin B is an antifungal medication notable for its toxicity and restricted use in treating fungal infections, and it serves as a reference standard in sensitivity testing against other antifungal agents.
From: World Journal of Pharmaceutical Research
(1) An antifungal medication that is the first-line treatment for mucormycosis, known for its effectiveness in combating severe fungal infections.[1] (2) The drug of choice for the treatment of PAM, known for its antifungal properties and used in treating N. fowleri infections.[2] (3) A reference antifungal agent used in antimicrobial studies to measure the antifungal activity of copolymers.[3] (4) The first-line antifungal treatment for mucormycosis, it acts by binding to sterols in the fungal cell membrane, causing cell death.[4] (5) An antifungal medication used to treat invasive fungal infections including mucormycosis.[5]
From: International Ayurvedic Medical Journal
(1) An antifungal drug used as a standard in sensitivity testing to compare against other substances.[6]
From: The Malaysian Journal of Medical Sciences
(1) An antifungal agent used in the study that displayed the most effectiveness against various moulds.[7]