Significance of Acute toxicity study
An acute toxicity study, as described in the provided text, is a crucial assessment across various fields including Ayurveda, Science, and Health Sciences. It involves observing the adverse effects of a substance after a single or short-term exposure, often administered in a single high dose. The goal is to determine the safety profile of a substance, identify potential toxic effects, and establish safe dosage levels. These studies are performed according to established guidelines and involve monitoring animals for signs of toxicity, morbidity, or mortality.
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Acute toxicity study'
In Hinduism, acute toxicity studies investigate immediate adverse effects of substances. These studies, following specific guidelines, assess toxicity signs, symptoms, and potential harm in animals or rats after a single dose, aiming to determine safe levels and establish antidotes.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) An acute toxicity test was conducted to determine the LD 50 dose of Vishagna (Alstonia venenata R. Br.) Kashaya, which was administered orally at different dose levels.[1] (2) This study was conducted according to specific guidelines and involved administering the drug Kshara to albino rats at different dose levels, observing them for 24 hours, and then collecting blood and organs for analysis.[2] (3) The procedure performed to assess the harmful effects of the plant extract, which revealed no toxicity and no mortality of the rates upto 5000 mg / kg body weight with aqueous and Ethanol extract of Language Name Sanskrit Mashaparni.[3] (4) An acute toxicity study was conducted to determine the toxicity of Jayapala Beeja and Saindhavadi Yoga in animals. The study aimed to observe the onset of toxic signs and symptoms, and to assess the effects of the drug on them. These studies are used to establish antidotes.[4] (5) This refers to the study performed to determine the adverse effects of Nagapashana Pishti in Sprague Dawley rats, following OECD guideline 420, as detailed in the provided text.[5]
From: Journal of Ayurvedic and Herbal Medicine
(1) This is a study that was conducted, in which two mortalities were found in rats given Haratal bhasma at a higher dose, which was used to establish the safe use of the bhasma form.[6] (2) This refers to the investigation of the immediate adverse effects resulting from a single dose of a substance, as described within the context of the given materials.[7]
From: International Research Journal of Ayurveda and Yoga
(1) This is an investigation to determine the safety of the drug for internal administration.[8]
The concept of Acute toxicity study in scientific sources
Acute toxicity study, as defined by the text, is a short-term investigation to assess a substance's potential harmful effects after a single or short-term exposure. It involves administering varying doses to animals, following established protocols like OECD guidelines, to determine safety levels, adverse effects, and lethal doses (LD50).
From: International Journal of Pharmacology
(1) The present investigation is a sequel of the previous acute toxicity study of this extract, which warranted the Melastoma leaf extract safe for oral ingestion at a single dose administration.[9] (2) This study was designed to elucidate the toxicity of the widely used fruit gum of Aegle marmelos in rats with total whole aqueous solution.[10] (3) The LD50 of A. cygnea and P. clarkii hemolymph was determined according to this study described by Chinedu et al.[11] (4) The results of this study showed the LD50 to be 55.9 mg kg -1, while the sub-lethal dose of LD20 and LD10 were 40.1 and 36.5 mg kg -1, respectively.[12] (5) The results from acute toxicity OECD 423 guidelines revealed that there was no record of any toxicity symptoms and mortality of animals from each dose of the extract via oral treatment.[13]
From: Asian Journal of Pharmaceutics
(1) A study that showed that methanolic extract of B. monosperma gum showed no mortality or toxic reaction at a fixed dose.[14] (2) The newly prepared polyherbal formulation was evaluated to antihyperglycemic effects in Wistar rats and furthermore the formulation was accessed for this.[15] (3) This study investigated the toxic effects of EETI in albino Wistar rats, finding no mortality up to 2000 mg/kg.[16] (4) Animals were randomly allotted in five groups (each group contain six mice) for this study.[17] (5) This study involves the evaluation of the toxic effects of white and black Gunja pericarps.[18]
From: Journal of Medicinal Plants for Economic Development
(1) The acute toxicity study is an evaluation performed to assess the immediate harmful effects of a substance or extract, often conducted on animals.[19] (2) This is the method used to determine the potential harmful effects of the extracts and isolated compounds, providing information about their safety profiles in the investigation.[20] (3) The acute toxicity study revealed that oral administration of SLD was found to be safe up to the dose of 2000 mg/kg bw and produced no signs of toxicity.[21] (4) This involves determining the harmful effects of a substance when administered in a single dose, as performed using the guidelines of the Organization for Economic Cooperation and Development.[22] (5) This is a scientific investigation that assesses the adverse effects of a substance following a single or short-term exposure, typically in animals.[23]
From: The Malaysian Journal of Medical Sciences
(1) An evaluation conducted to assess the safety and potential harmful effects of a substance at high doses over a short period.[24]
From: International Journal of Pharmacology
(1) A study conducted to determine the potential harmful effects of a substance when administered in a single dose or over a short period.[25] (2) An acute toxicity study was conducted following OECD-423 guidelines to determine the safety and potential toxic effects of the drug EEPM administered orally to rats.[26] (3) An assessment performed according to established guidelines to determine the potential harmful effects of substances when administered in a single dose or over a short period.[27] (4) This is a procedure to determine the safety of a substance by administering varying doses to animals and observing for adverse effects or mortality.[28] (5) A study conducted to determine the toxicity class and LD50 of a compound following specific guidelines.[29]