Significance of Acute Toxicity Studies
Acute Toxicity Studies are experiments designed to assess the harmful effects of substances following a single or short-term exposure, typically involving high doses administered to test subjects. These studies monitor adverse effects to determine safety and lethal dosages, often adhering to established protocols such as OECD guidelines. They have been conducted on various substances, including plant extracts, to evaluate their safety profiles. Findings from such studies help ensure that medicinal preparations are safe for use in living organisms.
Synonyms: Short-term toxicity studies, Acute toxicity testing., Safety evaluation, Risk assessment, Dose-response assessment, Hazard identification.
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Acute Toxicity Studies in scientific sources
Acute Toxicity Studies evaluate the safety of substances through high-dose tests on living organisms and short-term exposure assessments, determining safety profiles and toxic effects for various substances like Morinda pubescens, Opuntia fruit juice, and Septilin Drops.
From: World Journal of Pharmaceutical Research
(1) Studies designed to evaluate the potential harmful effects of substances administered to animal models over a short period.[1] (2) Research conducted to evaluate the harmful effects of compounds in the short-term, particularly concerning Hémodya and its use in sickle cell disease.[2] (3) Acute toxicity studies evaluate the safety profile of HAEAT at high doses to ensure no harmful effects occur upon administration prior to further testing.[3] (4) Research conducted to assess the harmful effects of substances after a short-term exposure, performed on the extracts of Swietenia mahogani's leaves and stem barks.[4] (5) Experiments designed to observe the immediate effects of high doses of substances, particularly the ethanolic extract, on living organisms.[5]
From: Ancient Science of Life
(1) Experiments conducted to evaluate the toxic effects and safe dosage levels of a substance over a short period.[6] (2) Experiments conducted to evaluate the safety and possible adverse effects of Mimosa Pudica's aqueous extract on animal subjects.[7] (3) Experiments conducted to assess the toxic effects and mortality of the drug on albino mice when administered in varying doses.[8] (4) Experiments conducted to evaluate the safety and non-toxicity of the crude alcoholic extracts in albino mice.[9] (5) Experiments conducted to assess the safety and potential harmful effects of the saponin extracts on living organisms.[10]
From: Journal of Ayurveda and Integrative Medicine
(1) Experiments designed to evaluate the adverse effects of D. hamiltonii at various doses over a short period, conducted in albino rats.[11] (2) Tests conducted to assess the safety and toxicity of the herbal cocktail using both chick embryos and mice.[12] (3) Acute toxicity studies are evaluations that determine the harmful effects of a substance after a single or short-term exposure.[13] (4) Experiments carried out to assess the toxic effects of the herbal formulation in Swiss mice, following OECD guidelines.[14] (5) Experiments designed to assess the effects of a substance on living organisms, typically involving high doses over a short duration.[15]
From: AYU (Journal of Research in Ayurveda)
(1) Experiments conducted to evaluate the harmful effects of a substance after a single dose or over a short period.[16] (2) Research conducted to determine the safety and potential side effects of bioactive compounds when administered at high concentrations.[17] (3) Tests conducted to assess the safety of substances, determining that the water extract of Morinda pubescens is safe at certain doses.[18] (4) Experiments conducted to assess the harmful effects of a substance after a short-term exposure, in accordance with OECD guidelines.[19] (5) Experiments conducted to assess the safety of substances at high doses in living organisms.[20]
From: Journal of Ayurveda and Holistic Medicine
(1) Research conducted to evaluate the safety profile of Septilin Drops concerning its potential toxic effects after administration.[21]