Significance of Acute toxicity
Acute toxicity is defined as the harmful effects of a substance following short-term exposure, often resulting from a single high dose. It is assessed through various studies, including behavioral responses in animals and measuring median lethal doses (LD50). The effects manifest rapidly, indicating potential danger, particularly in aquatic life and specific tested substances. Researchers evaluate acute toxicity to understand safety profiles and adverse reactions, as illustrated in various studies involving different compounds and extracts.
Synonyms: Short-term toxicity, High toxicity, Severe toxicity, Poisoning, Lethal concentration
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Acute toxicity in scientific sources
Acute toxicity involves harmful effects from brief exposure to a substance, such as high doses of vitamin A, which can cause immediate adverse symptoms and pose serious health risks.
From: World Journal of Pharmaceutical Research
(1) The harmful effects of a substance after a short-term exposure, evaluated in this study using different doses of PAEE in albino rats.[1] (2) The assessment of potential adverse effects of a substance after a short-term exposure, determined through controlled animal testing.[2] (3) The harmful effects that a substance, such as the aqueous extract, may have when administered in a single or short-term exposure.[3] (4) The toxicity produced by a pharmaceutical when administered in one or more doses during a period not exceeding 24 hours.[4] (5) A measure of the harmful effects of a substance that result from a single exposure, assessed in the study through specific protocols on animals.[5]
From: Ancient Science of Life
(1) A type of toxicity characterized by harmful effects observed shortly after exposure to a substance, evaluated in the context of Vangabhasma.[6] (2) The potential harmful effects of a substance, explored in the study using various dosages of the drug decoction.[7] (3) The immediate harmful effects experienced following excessive consumption of ethanol, including motor function impairment and mental confusion.[8] (4) The degree to which a substance can cause harmful effects following a short-term exposure.[9] (5) The potential harmful effects that may occur following administration of a substance in a single or short-term exposure, as observed in toxicity testing of T. zeylanicus.[10]
From: International Ayurvedic Medical Journal
(1) The immediate adverse effects observed after administering a high dose of a substance, specifically evaluated in female albino mice for Suryashekhara Rasa.[11] (2) The effects observed shortly after administering a high dose of a substance, in this case, Kaalakodi Rasam, on Wistar rats.[12] (3) The assessment of the adverse effects of a substance following a single exposure or multiple exposures within a short time frame.[13] (4) A type of toxicity study that evaluates the effects of a single exposure or multiple exposures of a short duration to a substance, here specifically referring to the trial formulation Vangachenduram.[14] (5) The harmful effects of a substance that occur shortly after a high dose, as studied in the first schedule of the research.[15]
From: Journal of Ayurveda and Integrative Medicine
(1) The assessment of the harmful effects of a substance that occur soon after exposure to a single high dose.[16] (2) The acute toxicity of AR leaf extract was assessed according to OECD guidelines.[17] (3) The harmful effects that occur shortly after a substance is administered, assessed in this study using doses of the methanolic extract in Wistar rats.[18] (4) Acute toxicity refers to the harmful effects of a substance when given in a single dose or in multiple doses within a short time frame, like the evaluation done on Tamra Bhasma.[19] (5) The immediate harmful effects that can occur after exposure to a toxic substance, assessed in studies of N. sativa.[20]
From: AYU (Journal of Research in Ayurveda)
(1) The study of harmful effects that result from a single exposure or multiple exposures in a short time frame, particularly pertaining to the Pepgard tablet in this research context.[21] (2) A study assessing the immediate harmful effects of a substance; in this case, bacnil capsule was tested for toxicity at doses up to 2000 mg/kg.[22] (3) The adverse effects of a substance that appear rapidly after exposure; studies suggest F. racemosa has a safe margin for traditional use.[23] (4) Acute toxicity refers to the harmful effects of a substance after a short term exposure, evaluated in this study with a dose of 2000 mg/kg.[24] (5) The harmful effects resulting from a single exposure or multiple exposures in a short period.[25]
From: The Malaysian Journal of Medical Sciences
(1) The harmful effects caused by exposure to a substance within a short period of time.[26] (2) The assessment of the harmful effects of a single or short-term exposure to a substance, in this case, the extract from Pandanus foetidus.[27] (3) Acute toxicity refers to the harmful effects of a substance that result from a single exposure or multiple exposures in a short period, often measured by the median lethal dose (LD50).[28]
From: Journal of Ayurveda and Holistic Medicine
(1) A sudden onset of adverse symptoms resulting from high doses of vitamin A, potentially leading to serious health complications.[29] (2) The adverse effects of a substance resulting from a single or short-term exposure.[30]
From: Ayushdhara journal
(1) The harmful effects observed after a single exposure to a toxic substance, in this case, evaluated through animal testing.[31]