Significance of Acute toxicity
Across Ayurveda, Science, and Health Sciences, acute toxicity consistently describes the adverse effects from a single or short-term exposure to a substance. These effects are often evaluated in animal studies, and can involve determining an LD50 value, or lethal dose for 50% of subjects. The studies aim to determine the safety profile of a substance, and can involve observing for signs of toxicity, mortality, and other adverse effects.
Synonyms: Short-term toxicity, High toxicity, Severe toxicity, Poisoning, Harmful exposure, Lethal concentration
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Acute toxicity'
In Hinduism, acute toxicity, as described in the text, refers to the immediate harmful effects of a substance after a single exposure. These effects are assessed through studies using various substances, including herbal drugs and extracts, on animals like mice and rats, and can range from non-lethal effects to death.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) Acute toxicity and in vivo laxative studies of Triphala extract in experimental animals provide information on its safety and potential effects on bowel movements.[1] (2) Acute toxicity refers to the adverse effects of a substance that result either from a single exposure or from multiple exposures in a short period of time, usually less than 24 hours.[2] (3) This refers to the immediate harmful effects, assessed through a method, after administering a single dose of the Simarouba glauca extract to the mice.[3] (4) This study was conducted to determine the LD 50 dose of Vishagna (Alstonia venenata R. Br.) Kashaya, as stated in the text provided for analysis.[4] (5) High amounts of glycoalkaloids taken by humans have caused acute intoxication, severe episodes of coma, and even death.[5]
From: Journal of Ayurvedic and Herbal Medicine
(1) Acute toxicity is a study conducted to determine the adverse effects of a substance when administered in a single dose, using albino mice as the subjects.[6] (2) This is a study conducted to assess the immediate toxic effects of Vanga Bhasma, given as a single dose.[7] (3) This refers to the harmful effects of a substance after a single exposure, and an acute oral toxicity study was performed to assess the safety of the extracts.[8] (4) This describes the adverse effects that can occur from a single or short-term exposure to a substance, such as an herbal drug, according to the text.[9] (5) This describes the effects of an alcoholic extract of B. ligulata on healthy Swiss albino mice.[10]
The concept of Acute toxicity in scientific sources
Acute toxicity refers to the immediate harmful effects after a single or short-term exposure to a substance. This is assessed through animal testing, observing symptoms, mortality rates, and other adverse effects. Studies determine dosage limits, safety margins, and lethal concentrations to evaluate the potential hazards of various substances.
From: International Journal of Pharmacology
(1) Acute toxicity studies revealed that C. ferruginea has a wide margin of safety profile, especially when administered orally.[11] (2) The acute toxicity test of methanolic extract, the parent extract of the alkaloids and glycosides, was determined in mice through intraperitoneal administration.[12] (3) A study was performed on male mice with increasing doses of the extract to determine mortality rate.[13] (4) Acute toxicity was assessed following the guidelines set by the OECD.[14] (5) The study observed mice for signs of this after extract administration.[15]
From: Asian Journal of Pharmaceutics
(1) Its detailed insights are provided by an ex vivo murine lung model, used to evaluate the toxicity of ethyl acrylate.[16] (2) This study involved randomly allotting animals into five groups and administering ethanol extract orally at different doses.[17] (3) Antioxidants can cause an including this, variety of side effects, skin and skin sensitization, eye irritation, and photosensitization.[18] (4) The immediate harmful effects of a substance, which was assessed for the polyherbal formulation according to OECD guidelines.[19] (5) It is the potential of the EETI seed to show any sign of mortality.[20]
From: Journal of Medicinal Plants for Economic Development
(1) This refers to the adverse effects of neem leaf meal in rats, with a reported LD50 value indicating the dose that would be lethal to half of the subjects.[21] (2) It is a study designed to evaluate the immediate adverse effects resulting from a single exposure to a substance, determining the dose at which it causes harm within a short observation period, particularly in animal models.[22] (3) This refers to the immediate adverse effects that are observed after a single administration of a substance, specifically in this context, evaluating the impact of different extracts on laboratory animals over a short period.[23] (4) This is the assessment of the potential harmful effects of the extracts and isolated compounds after a single dose, providing crucial safety information, which was determined.[24] (5) This is the adverse effects resulting from a single exposure to a substance, studied in the context of plant extracts, and assessed in animal models to determine the safety profile, as shown in the provided text.[25]
From: The Malaysian Journal of Medical Sciences
(1) A measure of the adverse effects of a substance after a single dose, which was tested for the extract at a high concentration, as noted in the provided text.[26] (2) This is the adverse effects that result from a single dose or a short-term exposure, which were determined for pulegone through oral and dermal routes in rats.[27] (3) The harmful effects caused by exposure to a substance within a short period of time.[28] (4) The assessment of the harmful effects of a single or short-term exposure to a substance, in this case, the extract from Pandanus foetidus.[29] (5) Acute toxicity refers to the harmful effects of a substance that result from a single exposure or multiple exposures in a short period, often measured by the median lethal dose (LD50).[30]
From: Onderstepoort Journal of Veterinary Research
(1) This term is used in the provided text to describe the study of NSAIDs induced effects on broiler chickens.[31] (2) This refers to the severe and rapid adverse effects that can result from high levels of oxalates in the diet of livestock.[32] (3) This refers to the adverse effects resulting from a single exposure to a substance, as observed in studies described in the text.[33]
From: Journal of Public Health in Africa
(1) This is one of the toxicity endpoints that can be predicted using the ProTox-II webserver.[34] (2) This describes the adverse effects of a substance after a single exposure, and is part of a study.[35]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) It refers to the adverse effects that occur within a short period, such as fatigue, sore throat, and radiation dermatitis.[36] (2) The EURAM only includes carcinogenicity, which is more conservative than acute toxicity on the health hazard score, even if a chemical has both acute toxicity and carcinogenicity.[37] (3) refers to the immediate harmful effects of a substance, with paraquat being known for its high acute toxicity and adverse effects on human health.[38] (4) Potential acute toxicity refers to the immediate harmful effects that heavy metals can have on organisms in sediments, which can be estimated.[39] (5) Refers to the potential of certain active substances to cause immediate and severe adverse health effects on the nervous system of florists upon exposure.[40]
From: Sustainability Journal (MDPI)
(1) Acute toxicity data was utilized in this study, with AF being 1000, and PNEC values were obtained from EC 50 data available in the literature.[41] (2) This refers to the immediate and severe harmful effects of neonics on pollen pickers, leading to a high mortality rate.[42] (3) Acute toxicity in environmental compartments and health is a subarea of research, and there are toxicity modeling techniques used for chemical mixtures, though their application in ecotoxicological studies is lacking.[43] (4) Acute toxicity of pharmaceuticals has been shown to generate acute toxicity on aquatic organisms and long-term chronic effects owing to the continuous release and their pseudo-persistent character.[44] (5) The safe thresholds for acute toxicity in zebrafish and large crayfish, which are used to determine the inhibitory effects of nonanoic acid and palmitic acid, both individually and in combination, on M. aeruginosa.[45]
From: International Journal of Pharmacology
(1) An evaluation of the adverse effects of a substance when administered in a single dose or over a short period, often determined by mortality rates.[46] (2) The toxicity of compounds when administered orally or parenterally, investigated to determine safety profiles and LD50 values.[47] (3) The adverse effects of a substance that occur rapidly after a single exposure or short period.[48] (4) An evaluation to determine the harmful effects of a substance at a high dose, assessing mortality and signs of toxicity over a specified period.[49] (5) The oral and parenteral acute toxicity of the synthesized compounds was investigated to determine their safety profile, with most compounds showing a high margin of safety.[50]