Significance of Acetic acid induced writhing test
The Acetic acid induced writhing test is an experimental method employed to assess analgesic effects in animals by monitoring the number of writhing movements following the administration of acetic acid. This test acts as a model for evaluating analgesic activity, particularly observing the contraction of abdominal muscles in response to acetic acid injection in rodents. It aids in gauging the pain-relieving efficacy of various compounds, providing critical insight into their anti-nociceptive properties.
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The concept of Acetic acid induced writhing test in scientific sources
The Acetic acid induced writhing test is a model for evaluating peripheral analgesic activity, using acetic acid to induce writhing in mice, and assessing analgesic effects by counting the resultant writhes or observing abdominal muscle contractions.
From: World Journal of Pharmaceutical Research
(1) A procedure utilized to measure the pain response in rats, confirming the anti-inflammatory efficacy of PD extract in this study.[1] (2) A model used to evaluate analgesic activity, where acetic acid is injected to induce writhing behavior in mice.[2] (3) A method used to assess peripheral analgesic activity by observing writhing responses in animals after administration of a 0.6% acetic acid solution.[3] (4) An experimental assessment used to evaluate the anti-nociceptive activity of Tecoma stans in test subjects.[4] (5) A pain measurement method involving the administration of acetic acid to rats, used to assess the analgesic efficacy of tested drugs.[5]
From: Ancient Science of Life
(1) A method used to assess peripheral analgesic effect by counting the number of wriths in response to pain induced by acetic acid.[6] (2) A method used to assess peripheral analgesic effects in mice by measuring the writhing response induced by acetic acid injection.[7]
From: AYU (Journal of Research in Ayurveda)
(1) A method used to assess analgesic activity by measuring the number of writhes produced in animals after injection of acetic acid.[8]
From: Ayushdhara journal
(1) An experimental method used to assess the pain-relieving effects of analgesics by observing writhing responses in animals after administration of acetic acid.[9]